Wearable biosensing device technology (^(M)Nature Reviews Materials, 2025) are becoming central to digital healthcare by enabling continuous physiological monitoring in daily life. Our research develops high-performance wearable sensors (^(ⅰ)Science Advances, 2017) and data-storage systems (^(ⅱ)Science Advances, 2016) through nanoscale material assembly and stretchable device engineering (^(ⅲ)Nature Nanotechnology, 2014) ensuring clinically reliable operation even under dynamic human motion. We created multimodal platforms capable of monitoring temperature, glucose, pH, and humidity, supporting applications such as wound-healing assessment, metabolic monitoring, and inflammation tracking. Integrated feedback modules further enable closed-loop therapeutic functions (^(ⅳ)Nature Nanotechnology, 2016). By combining biosensing with machine-learning–based signal interpretation, we also advance intuitive human-machine interfaces (^(ⅴ)Advanced Materials, 2014). Together, these technologies provide a foundation for continuous monitoring, early diagnosis, and personalized therapy with strong clinical translation potential.